Mpox global resurgence

Human mpox, a disease caused by the monkeypox virus (MPXV), is experiencing a global resurgence. A global outbreak caused by a Clade IIb virus occurred in 2022 and was declared a Public Heath Emergency of International Concern (PHEIC) by the World Health Organisation. A second PHEIC was delcared in 2024 due to the upsurge in Clade I cases in Central Africa.

It is now clear that MPXV has changed its interactions with humans across its entire endemic range and has emerged as a global threat with potential to occupy the human niche once occupied by smallpox.

We are working on multiple projects aimed at understanding host responses to MPXV, the basis of Mpox clades pathogenesis, and Mpox evolution.