Viral immune evasion

Our interests lay primarily in the study of the strategies employed by large DNA viruses, such as poxviruses and herpesviruses, to escape the host immune response and survive in infected cells as to complete their replicative cycle and establish new infections. Both pox and herpes viruses are enveloped viruses that deliver large (>150 kB) double-stranded DNA genomes coding for multiple proteins. Although fundamental differences exist in their replicative cycles, both families dedicate a great proportion of their vast coding capacity to manipulate the cellular environment and escape the host anti-viral response.